|
|
|
|
To examine the relation between prepregnant weight and the risk of neural tube defects(NTDs).Relative to women who weighed 50 to 59 kg,risk of NTDs increased from 1.9(95%confidence interval[CI],1.2 to 2.9)for women weighing 80 to 89 kg to 4.0(95%CI,1.6 to 9.9)for women weighing 110 kg or more.When women were classified according to daily intake above or below the recommended level of 400 ug of folate,approximate threefold increases in risk were estimated for the heaviest weights in both groups.Intakes of 400 ug of folate or more reduced risk of NTDs by 40%among women weighing less than 70 kg,but no risk reduction was observed among heavier women.The risk of NTDs increased with increasing prepregnant weight,independent of the effects of folate intake. |
|